本論文旨以反式-4-第三丁基二甲基矽氧基-L-脯胺酸與樟腦衍生之掌性有機催化劑催化偶氮二羧酸二苄基酯與一系列之醛類進行不對稱胺化反應，建立以R組態為主的具有光學活性之產物。探討一系列溶劑、溫度、添加劑、反應物之當量數及催化劑之當量數對不對稱胺化反應之影響及探討，發現僅需1 mol%催化量的樟腦衍生之胺催化劑30，以二氯甲烷做為溶劑並在0 °C的條件下，即可成功將偶氮二羧酸二苄基酯與醛類進行不對稱胺化反應，得到高達78 – >99%之產率與92 – 99%之鏡像選擇性。

This thesis reported the application of camphor-derived-(2S,4R)-4- OTBS-L-prolinamide as a chiral organo catalyst in the asymmetric amination reaction of aldehydes with dibenzyl azodicarboxylate. We found that 1.0 mol% catalyst 30 was able to catalyze the asymmetric amination of aldehydes with dibenzyl azodicarboxylate without any additive to afford chiral amination adduct with up to 99% ee (R) in excellent yields.

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