ABSTRACT
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本文介紹了過渡金屬催化的新發展,以有機轉化合成含氮與氧的環化或非環化合物,依據轉化的類型,本篇論文分為五個章節.
第一章節描述用金催化1-氨基-2-芳基-1-炔類與烯烃類化合物,行分子間{4+2}環化加成.此反應會形成gold carbenoid型式的中間體,並適用於多種電子密度高的烯烃類以及芳香族和雜環類炔醯胺. 炔醯胺化學在近十年被高度探討,因為它的穩定性與反應性,且開啟了通往新立體選擇與分子內反應的大門,此在傳統的炔醯胺是不可能的.
第二章描述用金催化氨炔類化合物行1,2-雙官能基轉化,藉一外部的氧化劑行一鍋化反應產生1,2-氨醇. 1,2-雙官能基轉化在烯類常見,但很少見在炔類.此一鍋化合成1,2-氨醇,突顯新催化的重要性.
第三章節描述金屬催化3-烯-1-炔醯胺,行[4+1]環化加成反應以合成2-氨呋喃, 在金屬幫助下環化加成1,3共振化合物與小分子,發現在有機合成具有廣泛的應用性, 呋喃衍生物由3-烯-1-炔醯胺與外加氧化劑合成而得,突顯新催化的重要性.
第四章描述一價金催化炔基酯,以串聯分子間[3+2]環化加成反應可高效合成高度官能基化的2,3-二氫呋喃.再多種雜環化合物中, 二氫呋喃衍生物被廣泛研究,因為其為許多天然物的重要亞基.
第五章描述一價金催化3-烯-1-炔二氧化噻嗪行oxoamination,用硝酮當外部氧化劑.高效合成大範圍的oxoamination衍生物的方法被開發出來。

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