研究生: |
朱葦翰 Chu, Wei-Han |
---|---|
論文名稱: |
多球體偵檢器度量醫用直線加速器環境中子能譜與劑量研究 Neutron Spectra and Doses Study around a Medical Linear Accelerator employing Bonner Sphere Spectrometers |
指導教授: |
董傳中
Tung, Chuan-Jong 莊克士 Chuang, Keh-Shih |
口試委員: | |
學位類別: |
碩士 Master |
系所名稱: |
原子科學院 - 生醫工程與環境科學系 Department of Biomedical Engineering and Environmental Sciences |
論文出版年: | 2010 |
畢業學年度: | 98 |
語文別: | 中文 |
論文頁數: | 115 |
中文關鍵詞: | 多球體偵檢器 、光中子能譜 、光核反應 |
外文關鍵詞: | Bonner sphere spectrometer, photoneutron spectrum, photonuclear reaction |
相關次數: | 點閱:2 下載:0 |
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醫用直線加速器(linear accelerator,LINAC)為現今放射腫瘤科最主要治療癌症之技術,對於深部的病灶常予以高能量光子射束照射,然而,當光子能量超過6.2 MeV時,光子會與治療機頭(treatment head)內高原子序數之物質作用產生光中子(photoneutron),由於中子屬於強穿輻射(strongly penetrating radiation),存在於機頭內的光中子會直接穿透屏蔽光子之物質滲漏至加速器的環境中,藉由多次碰撞(multiple collisions)及散射,分佈於治療室(treatment room)與迷道(maze)中,造成其環境周遭不必要之中子劑量(undesirable neutron dose);本研究採用多球體偵檢器搭配計算中子能譜之程式用以計算照野外(out-off field)之中子通量,並轉換成中子劑量予以評估,同時也探討影響中子能譜變化之因子。建立此實驗技術,未來可提供輻射防護與臨床之參考,亦為保健物理領域中盡一份心力。
1.ICRP, The 2007 Recommendations of the International
Commission on Radiological Protection. 2007: Elsevier.
2.Chadwick, J., Possible existence of a neutron. Nature,
1932. 129(3252): p. 312.
3.Yao, W., Review of particle physics. Journal of Physics
G: Nuclear and Particle Physics, 2006. 33: p. 1.
4.陳俊良, 中子度量原理與實務. 2008.
5.Protection, I.C.o.R., Recommendations of the
International Commission on Radiological Protection.
1991: Pergamon Press Oxford.
6.ICRP, Conversion Coefficients for Use in Radiological
Protection against External Radiation 1996: Elsevier.
7.Valentin, J., The 2007 Recommendations of the
International Commission on Radiological Protection.
2007: Elsevier.
8.Morgan, H., NCRP Report 151 Structural shielding design
and evaluation for megavoltage x-and gamma-ray
radiotherapy facilities. Journal of Radiological
Protection, 2006. 26: p. 349.
9.Bedogni, R., et al., Determination and validation of a
response matrix for a passive Bonner sphere spectrometer
based on gold foils. Radiation measurements, 2008. 43(2-
6): p. 1104-1107.
10.Axton, E. and A. Bardell, Neutron production from
electron accelerators used for medical purposes. Physics
in Medicine and Biology, 1972. 17: p. 293-298.
11.Deye, J. and F. Young, Neutron production from a 10 MV
medical line. Physics in Medicine and Biology, 1977. 22:
p. 90-94.
12.Kry, S., et al., A Monte Carlo model for out-of-field
dose calculation from high-energy photon therapy.
Medical physics, 2007. 34: p. 3489.
13.Kry, S., et al., Neutron spectra and dose equivalents
calculated in tissue for high-energy radiation therapy.
Medical physics, 2009. 36: p. 1244.
14.Awotwi-Pratt, J. and N. Spyrou, Measurement of
photoneutrons in the output of 15 MV Varian Clinac 2100C
LINAC using bubble detectors. Journal of Radioanalytical
and Nuclear Chemistry, 2007. 271(3): p. 679-684.
15.Esposito, A., et al., Determination of the neutron
spectra around an 18 MV medical LINAC with a passive
Bonner sphere spectrometer based on gold foils and TLD
pairs. Radiation measurements, 2008. 43(2-6): p. 1038-
1043.
16.Barquero, R., et al., Neutron spectra and dosimetric
features around an 18 MV linac accelerator. Health
physics, 2005. 88(1): p. 48.
17.Holeman, G., et al., Neutron spectral measurements in an
intense photon field associated with a high-energy x-ray
radiotherapy machine. Medical physics, 1977. 4: p. 508.
18.Zabihzadeh, M., et al., Monte Carlo estimation of
photoneutrons contamination from high-energy X-ray
medical accelerators in treatment room and maze: a
simplified model. Radiation Protection Dosimetry, 2009.
135(1): p. 21.
19.Kim, H., et al., Evaluation of the photoneutron field
produced in a medical linear accelerator. Radiation
Protection Dosimetry, 2007. 123(3): p. 323.
20.Followill, D., et al., Neutron source strength
measurements for Varian, Siemens, Elekta, and General
Electric linear accelerators. Journal of Applied
Clinical Medical Physics, 2003. 4(3): p. 189.
21.Vega-Carrillo, H., et al., Neutron spectrum and doses in
a 18 MV LINAC. Journal of Radioanalytical and Nuclear
Chemistry, 2010. 283(1): p. 261-265.
22.Howell, R., et al., Investigation of secondary neutron
dose for 18 MV dynamic MLC IMRT delivery. Medical
physics, 2005. 32: p. 786.
23.Ma, A., et al., Monte Carlo study of photoneutron
production in the Varian Clinac 2100C linac. Journal of
Radioanalytical and Nuclear Chemistry, 2008. 276(1): p.
119-123.
24.Vega-Carrillo, H., et al., H*(10) and neutron spectra
around linacs. Journal of Radioanalytical and Nuclear
Chemistry: p. 1-4.
25.Barquero, R. and R. Mendez, Thermoluminescence
measurements of neutron dose around a medical linac.
Radiation Protection Dosimetry, 2002. 101(1): p. 493.
26.Saeed, M., et al. Doses to Patients from Photo-Neutrons
Emitted in a Medical Linear Accelerator: Springer.
27.Chadwick, M., et al., Handbook of photonuclear data for
applications: Cross sections and spectra. IAEA TECH-DOC,
2000. 1178.
28.Alghamdi, A., A. Ma, and N. Spyrou, Calculation of the
photonuclear yield using an anthropomorphic phantom.
Journal of Radioanalytical and Nuclear Chemistry, 2007.
271(3): p. 639-642.
29.Tosi, G., et al., Neutron measurements around medical
electron accelerators by active and passive detection
techniques. Medical physics, 1991. 18: p. 54.
30.Vega-Carrillo, H., et al., Study of room-return
neutrons. Radiation measurements, 2007. 42(3): p. 413-
419.
31.Vega-Carrillo, H.R. Neutron Spectra In A 15 MV LINAC. in
IX MEXICAN SYMPOSIUM ON MEDICAL PHYSICS. 2010. Mexico.
32.Bartlett, D., et al., Concepts and quantities in
spectrometry and radiation protection. Radiation
Protection Dosimetry, 2003. 107(1-3): p. 23.
33.Sato, T., et al., Fluence-to-dose conversion
coefficients for neutrons and protons calculated using
the PHITS code and ICRP/ICRU adult reference
computational phantoms. Physics in Medicine and Biology,
2009. 54: p. 1997.
34.Thomas, D. Neutron Spectrometry. in International
Radiation Protection Association 11th International
Congress. 2009. South Africa.
35.Sanchez, G., T. Arteaga, and J. Rodriguez, Neutron
Spectra Unfolding with Artificial Neural Networks.
Encuentro de Investigación en Ingeniería Eléctrica, 2005.
36.Vega-Carrillo, H., et al., Response matrix of a
multisphere neutron spectrometer with an^ 3He
proportional counter. Revista Mexicana de Fisica, 2005.
51(1): p. 47.
37.Bedogni, R., A. Esposito, and M. Chiti, Determination of
workplace neutron spectra at a high energy hadron
accelerator using active and passive Bonner sphere
spectrometers. Radiation measurements, 2008. 43(2-6): p.
1113-1117.
38.Gallego, E., et al., BSS/6 LiI Response Matrix to
neutrons from 2.5 E (-8) to 100 MeV.
39.Hajek, M., et al. Comparison of measurements with active
and passive Bonner sphere spectrometers. 2000.
40.Silari, M., et al., Intercomparison of radiation
protection devices in a high-energy stray neutron field.
Part III: Instrument response. Radiation measurements,
2009.
41.Gregori, B., S. Papadopulos, and J. Cruzate, Multisphere
Neutron Spectrometric System with Thermoluminescence
Dosemeters: Sensitive Improvement. Radiation Protection
Dosimetry, 2002. 101(1-4): p. 133.
42.Van Eijk, C., Neutron detection and neutron dosimetry.
Radiation Protection Dosimetry, 2004. 110(1-4): p. 5.
43.Thomas, D., Neutron spectrometry for radiation
protection. Radiation Protection Dosimetry, 2004. 110(1-
4): p. 141.
44.Brooks, F. and H. Klein, Neutron spectrometry--
historical review and present status. Nuclear
Instruments and Methods in Physics Research Section A:
Accelerators, Spectrometers, Detectors and Associated
Equipment, 2002. 476(1-2): p. 1-11.
45.Bedogni, R., et al., FRUIT: An operational tool for
multisphere neutron spectrometry in workplaces. Nuclear
Instruments and Methods in Physics Research Section A:
Accelerators, Spectrometers, Detectors and Associated
Equipment, 2007. 580(3): p. 1301-1309.
46.Mendez, R., et al., Study of the neutron field in the
vicinity of an unshielded PET cyclotron. Physics in
Medicine and Biology, 2005. 50: p. 5141.
47.Reginatto, M., Resolving power of a multisphere neutron
spectrometer. Nuclear Instruments and Methods in Physics
Research Section A: Accelerators, Spectrometers,
Detectors and Associated Equipment, 2002. 480(2-3): p.
690-695.
48.Wiegel, B. and A. Alevra, NEMUS--the PTB Neutron
Multisphere Spectrometer: Bonner spheres and more.
Nuclear Instruments and Methods in Physics Research
Section A: Accelerators, Spectrometers, Detectors and
Associated Equipment, 2002. 476(1-2): p. 36-41.
49.Hertel, N. and J. Davidson, The response of Bonner
spheres to neutrons from thermal energies to 17.3 MeV.
Nuclear Instruments and Methods in Physics Research
Section A: Accelerators, Spectrometers, Detectors and
Associated Equipment, 1985. 238(2-3): p. 509-516.
50.Thomas, D. and A. Alevra, Bonner sphere spectrometers--a
critical review. Nuclear Instruments and Methods in
Physics Research Section A: Accelerators, Spectrometers,
Detectors and Associated Equipment, 2002. 476(1-2): p.
12-20.
51.Cruzate, J., J. Carelli, and B. Gregori, Bonner Sphere
Spectrometer.
52.Johnson, T., et al. Recent advances in Bonner sphere
neutron spectrometry. 1987.
53.Tripathy, S., et al., Measurement of 241Am-Be spectra
(bare and Pb-covered) using TLD pairs in multi-spheres:
Spectrum unfolding by different methods. Nuclear
Instruments and Methods in Physics Research Section A:
Accelerators, Spectrometers, Detectors and Associated
Equipment, 2009. 598(2): p. 556-560.
54.Wiegel, B., et al., Intercomparison of radiation
protection devices in a high-energy stray neutron field,
Part II: Bonner sphere spectrometry. Radiation
measurements, 2009. 44(7-8): p. 660-672.
55.Vega-Carrillo, H., Neutron energy spectra inside a PET
cyclotron vault room. Nuclear Instruments and Methods in
Physics Research Section A: Accelerators, Spectrometers,
Detectors and Associated Equipment, 2001. 463(1-2): p.
375-386.
56.Bramblett, R., R. Ewing, and T. Bonner, A new type of
neutron spectrometer. Nuclear instruments and Methods,
1960. 9(1): p. 1-12.
57.Reginatto, M., What can we learn about the spectrum of
high-energy stray neutron fields from Bonner sphere
measurements? Radiation measurements, 2009. 44(7-8): p.
692-699.
58.Harshaw TLD Model 3500, Manual Reader. 2007: Thermo
Fisher Scientific Inc.
59.Hsu, F., et al., Estimation of photon and neutron dose
distributions in the THOR BNCT treatment room using dual
TLD method. Radiation measurements, 2008. 43(2-6): p.
1089-1094.
60.Vega-Carrillo, H., TLD pairs, as thermal neutron
detectors in neutron multisphere spectrometry. Radiation
measurements, 2002. 35(3): p. 251-254.
61.Vega Carrillo, H., et al., Response Matrix for a
Multisphere Spectrometer using a 6LiF Thermoluminescence
Dosemeter. Radiation Protection Dosimetry, 1999. 81(2):
p. 133.
62.謝明崇, 中子偵檢器校正與實務研討. 2004, 核能研究所.
63.朱健豪, 中子校正系統性能評估之研究. 1998, 核能研究所.
64.Carrillo, H.R.V. and N. Hertel, Application of Bonner
spheres spectrometer In Californium-252 neutron field
dosimetry.
65.Bohm, J., et al., ISO recommended reference radiations
for the calibration and proficiency testing of
dosemeters and dose rate meters used in radiation
protection. Radiation Protection Dosimetry, 1999. 86(2):
p. 87.
66.Mares, V. and H. Schraube, Evaluation of the response
matrix of a Bonner sphere spectrometer with LiI detector
from thermal energy to 100 MeV. Nuclear Instruments and
Methods in Physics Research Section A: Accelerators,
Spectrometers, Detectors and Associated Equipment, 1994.
337(2-3): p. 461-473.
67.Matzke, M., Unfolding methods, Report on work performed
at the Physikalisch Technische Bundesanstalt (PTB)
Braunschweig, URL= http://www. matzke. gmxhome.
de/Dateien/Theory. pdf.
68.Sweezy, J., N. Hertel, and K. Veinot, BUMS--Bonner
sphere Unfolding Made Simple: an HTML based multisphere
neutron spectrometer unfolding package. Nuclear
Instruments and Methods in Physics Research Section A:
Accelerators, Spectrometers, Detectors and Associated
Equipment, 2002. 476(1-2): p. 263-269.
69.Reginatto, M. and P. Goldhagen, MAXED, a computer code
for maximum entropy deconvolution of multisphere neutron
spectrometer data. Health physics, 1999. 77(5): p. 579.
70.Reginatto, M., P. Goldhagen, and S. Neumann, Spectrum
unfolding, sensitivity analysis and propagation of
uncertainties with the maximum entropy deconvolution
code MAXED. Nuclear Inst. and Methods in Physics
Research, A, 2002. 476(1-2): p. 242-246.
71.Esposito, A. and M. Nandy, Measurement and unfolding of
neutron spectra using Bonner spheres. Radiation
Protection Dosimetry, 2004. 110(1-4): p. 555.
72.Reginatto, M., The 'few channel' unfolding programs in
the UMG package. . 2004: PTB.
73.Howell, R., et al., Measurements of secondary neutron
dose from 15 MV and 18 MV IMRT. Radiation Protection
Dosimetry, 2005. 115(1-4): p. 508.
74.Kralik, M. and K. Turek, Characterisation of neutron
fields around high-energy x-ray radiotherapy machines.
Radiation Protection Dosimetry, 2004. 110(1-4): p. 503.
75.Thomas, D., A. Bardell, and E. Macaulay,
Characterisation of a gold foil-based Bonner sphere set
and measurements of neutron spectra at a medical
accelerator. Nuclear Instruments and Methods in Physics
Research Section A: Accelerators, Spectrometers,
Detectors and Associated Equipment, 2002. 476(1-2): p.
31-35.
76.Zanini, A., et al., Neutron spectra in a tissue
equivalent phantom during photon radiotherapy treatment
by LINACS. Radiation Protection Dosimetry, 2004. 110(1-
4): p. 157.
77.Kase, K., et al., Neutron fluence and energy spectra
around the Varian Clinac 2100C/2300C medical
accelerator. Health physics, 1998. 74(1): p. 38.
78.黎俊蔚, 多球體度量中子能譜技術及校正與應用, in 原子科學
系. 1982, 國立清華大學: 台灣.
79.金啟明, 核一廠中子人員劑量計的校正與評估, in 原子科學系.
1984, 國立清華大學: 台灣.
80.朱健豪, 超熱中子濾屏之評估, in 生醫工程與環境科學系.
1994, 國立清華大學: 台灣.
81.許榮鈞, 中子伴隨遷移計算之研究與應用, in 工程與系統科學
系. 1992, 國立清華大學: 台灣.
82.龔俊宏, 以 MCNP 模擬中子偵檢器之能量回應函數, in 生醫工程
與環境科學系. 1994, 國立清華大學: 台灣.