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研究生： 王弘軒
論文名稱： 以相位對比磁振造影進行視覺化及定量化分析馬凡氏症患者之主動脈血流
Visualization and Quantification of Aortic Flow for Marfan Syndrome Patients by Phase-Contrast Magnetic Resonance Imaging
指導教授： 彭旭霞
口試委員: 曾文毅
王福年
鍾孝文
吳文超
學位類別： 碩士
Master
系所名稱： 原子科學院 - 生醫工程與環境科學系
Department of Biomedical Engineering and Environmental Sciences
論文出版年： 2014
畢業學年度： 102
語文別： 英文
論文頁數： 85
中文關鍵詞： 主動脈血流 、馬凡氏症 、相位磁振造影
相關次數： 點閱：3  下載：0 
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    • 本篇研究的目的是，透過有症狀的馬凡氏症患者與正常受試者的比較，視覺化及量化主動脈血流在其流動模式及血液動力學相關參數上的變化。針對十七位馬凡氏症患者 (年齡：28.35 ± 12.84 歲)及九位年齡匹配的正常受試者 (年齡：26.67 ± 8.92 歲)，其主動脈內的流動模式及血液動力學相關參數是透過四維的相位對比核磁共振造影的影像達到視覺化及量化。馬凡氏症患者其主動脈根的直徑顯著大於正常受試者(3.93 ± 0.86 毫公分 vs. 2.53 ± 0.38毫公分 ，p值小於0.001). 主動脈血流是利用商業程式視覺化。血流對時間之曲線、膨脹性、回流分數、渦度、螺旋度、壁面切應力、震盪剪切指數和非圓度都會被計算在散佈整個主動脈的分析平面內。評估壁面切應力分布的非圓度在平面2和平面8都變化了 (p值分別小於0.05及0.01)。在某些平面上，不管是軸向及圓周向的壁面切應力或是其實際大小，在整圈的血管壁上有部分的差異。這些發現都指出了在兩受試群之間，血流模式和血液動力學相關參數的差異可能與動脈剝離的高風險有關。

    Chapter 1 Introduction 1 1.1 Marfan Syndrome 1 1.1.1 Genetic Basis and Pathogenesis 1 1.1.2 Aortic Complications 3 1.1.3 Treatment in MFS 6 1.2 Diagnosis of MFS 8 1.2.1 Ultrasound 8 1.2.2 X-ray Computed Tomography (CT) 10 1.2.3 Cardiovascular Magnetic Resonance 11 1.3 Motivation 16 Chapter 2 Theory 17 2.1 PC-MRI 17 2.2 4D Flow-Sensitive MRI 20 Chapter 3 Materials and Methods 23 3.1 Study Cohort 23 3.2 MRI Acquisition 25 3.3 Data Analysis Process 27 3.4 Visualization 30 3.4.1 Pathline 30 3.4.2 Vector 31 3.5 Hemodynamic Parameters 32 3.5.1 Distensibility 32 3.5.2 Retrograde Fraction 33 3.5.3 Vorticity 34 3.5.4 Helicity 36 3.6 Wall Shear Stress 37 3.7 Oscillatory Shear Index 39 3.8 Non-Roundness 40 3.9 Statistical Analysis 40 Chapter 4 Results: Visualization 41 4.1 Pathline 41 4.2 Vector 45 Chapter 5 Results: Quantification 46 5.1 Flow Rate-Time curve 46 5.2 Hemodynamic Parameters 47 5.2.1 Distensibility 47 5.2.2 Retrograde Fraction 48 5.2.3 Vorticity 49 5.2.4 Helicity 50 5.3 Wall Shear Stress 51 5.3.1 Plane Analysis 51 5.3.2 Regional Analysis 53 5.4 Oscillatory Shear Index 56 5.5 Non-Roundness 57 5.5.1 Non-Roundness 57 5.5.2 Normalized Non-Roundness 60 Chapter 6 Discussion: Visualization 63 6.1 Pathline 63 6.2 Vector 65 Chapter 7 Discussion: Quantification 66 7.1 Hemodynamic Parameters 66 7.1.1 Flow rate vs. time 66 7.1.2 Distensibility 66 7.1.3 Retrograde Fraction 67 7.1.4 Vorticity 68 7.1.5 Helicity 69 7.2 Wall Shear Stress 71 7.3 Oscillatory Shear Index 73 7.4 Non-Roundness 75 Chapter 8 Conclusions 76 8.1 Conclusions 76 8.2 Future Work 77 Chapter 9 References 78

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