胃幽門螺旋桿菌是人體胃部的病源菌，其感染胃部黏膜層將會導致慢性胃炎、消化性潰傷、胃癌和粘膜相關性淋巴瘤。胃幽門螺旋桿菌26695編號的hp1139基因可轉譯出染色體分配系統中的動源蛋白HpSoj和DNA結合蛋白HpSpo0J。在之前研究中，HpSoj 經由凝膠遷移具有與DNA的結合能力、孔雀石綠ATP活性分析知水解活性與HpSpo0J作用的能力。這非常值得在蛋白質晶體學上從結構的角度來探討HpSoj如何與DNA結合和如何與HpSpo0J作用。本研究成功獲得 HpSoj-ATP複合物晶體，並經由X-ray晶體繞射達到1.9 Å的解析度，利用分子置換的方式解析出 HpSoj-ATP複合物晶體結構，其空間群屬於P212121，晶格參數為a = 48.1 Å, b = 93.3 Å, c = 110.9 Å。不對稱單元中含有兩個分子，其為二聚體之關係。HpSoj的結構為非典型的Rossmann 折疊，其由七個β摺板與兩對α螺旋組連結構成。根據蛋白質序列比對與HpSoj的結構以及先前之參考文獻指出，Soj透過必須性高序列保守度的正電荷氨基酸arginine對DNA的負電荷磷酸骨架有非專一性之結合能力。於HpSoj一級結構中，相對應之位置的氨基酸 Q194、F206、K227和K230並不具有序列性保守度，由於Q194與K230位置的arginine已被證實對於Soj與DNA之結合最為重要，推測提出HpSoj利用位在其二聚體結合面附近的lysine與DNA作用的假設。

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