研究生: |
潘昭銘 Pan, Zhao-Ming |
---|---|
論文名稱: |
整合式活化裝置用於清大硼中子捕獲治療射束中子能譜確認之理論與實驗測試 A theoretical and experimental test on the performance of an integrated activation device for neutron spectrum confirmation at THOR-BNCT |
指導教授: |
許榮鈞
Sheu, Rong-Jiun |
口試委員: |
薛燕婉
Liu, Hsueh Yen-Wan 蔡惠予 Tsai, Hui-Yu |
學位類別: |
碩士 Master |
系所名稱: |
原子科學院 - 核子工程與科學研究所 Nuclear Engineering and Science |
論文出版年: | 2021 |
畢業學年度: | 109 |
語文別: | 英文 |
論文頁數: | 136 |
中文關鍵詞: | 硼中子捕獲治療 、箔片活化 、中子能譜反解 、射束特性研究 、射束品保 |
外文關鍵詞: | Foil Activation, Neutron Spectrum Unfolding, Beam Characterization |
相關次數: | 點閱:2 下載:0 |
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為了增加THOR-BNCT設施的品保以及品管措施涵蓋範圍,本研究利用一新型整合式活化偵檢器(整合緩速中子的壓克力假體與七片活化箔片)並建立相關方法論,用以協助確定此設施硼中子捕獲治療中子射束的品質。該能譜確認裝置具有以下特性:只需三十分鐘的射束照射時間即可完成全部箔片的活化;全部實驗流程可在只使用一台高純度鍺偵檢器的狀況下,於一天之內完成。另外,藉由蒙地卡羅程式重新定義之個別箔片響應函數,接續的能譜反解工作可以非傳統方式進行,且依然取得可靠結果。本研究於2020年六月至2021年七月以九次實驗測試確認了此裝置的再現性及性能,並以理論模擬測試建立一個箔片反應率與中子能群變化關係的對照表。使用者可參考此表上的關係,立即從實驗結果判斷THOR-BNCT設施的中子能譜是否發生改變。總體而言,此項裝置可快速偵測中子能譜是否產生變化並量化改變幅度,可用於確認照射條件是否符合設施原本設計。因此,本論文建議可將此裝置作為每月或是每季的品保以及品管措施,以更加提升目前THOR-BNCT設施的品質管理。
To extend the domain of subjects examined in current QA/QC measures in THOR-BNCT facility, this study constructed a methodology based on an integrated activation device integrating PMMA phantom and 7 foils aiming to assure the BNCT beam quality. It requires only 30 minutes beam time and all the process of which can be finished within a day using single HPGe. Additionally, spectrum unfolding can be achieved in an unorthodox yet reliable way using redefined foil response functions calculated by MCNP. From June, 2020 to July, 2021, there are 9 experimental tests conducted which verify the reproducibility and performance of this device. There are also theoretical tests based on simulation that construct a lookup table relating the foil reaction rate and flux variation of neutron groups. Through this table, users can immediately judge whether the neutron spectrum have varied or not on the basis of experiment result. Generally speaking, this device can provide a quick detection on the variation of neutron spectrum and quantify its amplitude. It is suitable for checking if the irradiation condition satisfies the facility's design. Therefore, the incorporation of this detector as a spectrum QA/QC measure in THOR-BNCT on a quarterly or monthly basis is recommended to better the current quality management in THOR-BNCT facility.
1. Current Status of Neutron Capture Therapy TECDOC Series 1223 (International
Atomic Energy Agency, Vienna, 2001).
2. Altieri, S. & Protti, N. A brief review on reactor-based neutron sources for boron
neutron capture therapy. Therapeutic Radiology and Oncology 2 (2018).
3. Kreiner, A. J. et al. Present status of Accelerator-Based BNCT. Reports of Practical
Oncology and Radiotherapy 21. 7th Young BNCT meeting, 95–101 (2016).
4. Dymova, M. A. et al. Boron neutron capture therapy: Current status and future
perspectives. Cancer Communications 40, 406–421 (2020).
5. Graham, J. et al. Neutron flux characterization techniques for radiation effects studies.
Journal of Radioanalytical and Nuclear Chemistry 291 (Feb. 2012).
6. ALQahtani, M. & Alajo, A. B. Characterization of prompt neutron spectrum of the
Missouri University of Science and Technology Reactor. Nuclear Engineering and
Design 320, 57–64 (2017).
7. Giegel, S. H. et al. Determination of the neutron energy spectrum of a radial neutron
beam at a TRIGA reactor. Nuclear Instruments and Methods in Physics Research
Section B: Beam Interactions with Materials and Atoms 454, 28–39 (2019).
8. Tanaka, T. et al. Measurement of neutron spectrum using activation method in deuterium
plasma experiment at LHD. Fusion Engineering and Design 146. SI:SOFT-
30, 496–499 (2019).
9. Liu, Y.-H. Neutronic Characterization of an Epithermal Neutron Beam in Boron
Neutron Capture Therapy PhD thesis (Institute of Nuclear Engineering and Science,
National Tsing Hua University, 2009).
10. Lin, H.-X. Characteristics and Application of a Spherical Type Activation-based Detector
for Neutron Spectrum Measurements at the THOR BNCT Facility MA thesis
(Institute of Nuclear Engineering and Science, National Tsing Hua University,
2014).
11. Huang, C.-K. Applications of Neutron Activation Analysis on Boron Neutron Capture
Therapy Institute of Nuclear Engineering and Science, National Tsing Hua
University. PhD thesis (2017).
12. Lee, T.-A. Development and Test of an Integrated Device for Spectrum Confirmation
at THOR-BNCT MA thesis (Institute of Nuclear Engineering and Science, National
Tsing Hua University, 2020).
13. Pietropaolo, A. et al. Neutron detection techniques from ueV to GeV. Physics Reports
875, 1–65 (2020).
14. McGregor, D. & Shultis, J. K. Radiation Detection: Concepts, Methods, and Devices
1st ed. (CRC Press, 2020).
15. Knoll, G. F. Radiation Detection and Measurement 4th ed. (John Wiley and Sons,
Ltd, 2010).
16. Gehrke, R. & Davidson, J. Acquisition of quality gamma-ray spectra with HPGe spectrometers.
Applied Radiation and Isotopes 62, 479–499 (2005).
17. Gilmore, G. R. Practical Gamma-Ray Spectrometry 2nd ed. (John Wiley and Sons,
Ltd, 2008).
18. GammaVision-32 Software User’s Manuel (A66-B32) (Advanced Measurement Technology,
Inc., 2006).
19. Jiang, S.-H. et al. The overview and prospects of BNCT facility at Tsing Hua Openpool
reactor. Applied Radiation and Isotopes 161, 109143 (2020).
20. Lin, Y.-C. Radiation Dose Rate Measurement in a Mixed Radiation Field Using
Paired Ionization Chambers PhD thesis (Department of Biomedical Engineering
and Environmental Science, National Tsing Hua University, 2013).
21. Attix, F. H. Introduction to Radiological Physics and Radiation Dosimetry 1st ed.
(John Wiley and Sons, Ltd, 1986).
22. Chang, C.-H. The Measurement of Neutron Fluence Rate for Tsing Hua Open-pool
Reactor Boron Neutron Capture Therapy Beam MA thesis (Department of Engineering
and System Science, National Tsing Hua University, 2004).
23. Brooks, F. & Klein, H. Neutron spectrometry—historical review and present status.
Nuclear Instruments and Methods in Physics Research Section A: Accelerators,
Spectrometers, Detectors and Associated Equipment 476. Int. Workshop on Neutron
Field Spectrometry in Science, Technology and Radiation Protection, 1–11 (2002).
24. Reginatto, M. Overview of spectral unfolding techniques and uncertainty estimation.
Radiation Measurements 45. Proceedings of the 11th Symposium on Neutron
and Ion Dosimetry, 1323–1329 (2010).
25. Bramblett, R. L. et al. A new type of neutron spectrometer. Nuclear Instruments
and Methods 9, 1–12 (1960).
26. Thomas, D. & Alevra, A. Bonner sphere spectrometers—a critical review. Nuclear
Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers,
Detectors and Associated Equipment 476. Int. Workshop on Neutron Field
Spectrometry in Science, Technology and Radiation Protection, 12–20 (2002).
27. Reginatto, M. & Goldhagen, P. MAXED, a computer code for the deconvolution of
multisphere neutron spectrometer data using the maximum entropy method tech.
rep. EML-595 (Environmental Measurements Laboratory, U.S. Department of Energy,
201 Varick Street, 5th Floor, New York, NY, June 1998).
28. Goffe,W. L. et al. Global optimization of statistical functions with simulated annealing.
Journal of Econometrics 60, 65–99 (1994).
29. NuDat 2 database accessed at: 2021-07-20. National Nuclear Data Center, Brookhaven
National Laboratory. https://www.nndc.bnl.gov/nudat2/.
30. Sheu, R.-J. Lecture Notes in Monte Carlo Method NES 505500. Institute of Nuclear
Engineering and Science, National Tsing Hua University (2021).
31. Werner, C. J. et al. MCNP version 6.2 release notes tech. rep. LA-UR-18-20808 (Los
Alamos National Lab, Los Alamos, NM, Feb. 2018).
32. Werner, C. J. et al. MCNP User’s manual Code Version 6.2 tech. rep. LA-UR-17-
29981 (Los Alamos National Lab, Los Alamos, NM, Oct. 2017).