本研究中我們以電噴灑式氣相奈米粒子流動分析儀(ES-DMA)為基礎，開發適用膠體混成式奈米材料之分析技術與方法，以量測膠體混成式奈米材料於水溶液相中的粒徑分布、濃度與膠體穩定性等。為了克服只使用單一量測技術造成的量測限制，我們結合不同分析技術之優勢，例如：以ES-DMA銜接上氣溶膠粒子重量分析儀(APM)，可量測膠體混成式奈米材料其重量參數;亦或是搭配氣溶膠式表面積分析儀(ASAA)，來量測水相中的膠體材料單粒平均表面積，以提升材料後端應用之價值。研究成果顯示我們可以針對分散型與混成式奈米材料所處之環境條件，量測對應之粒徑分布及數量濃度產生的變化，進而從定量上分析奈米材料在不同環境下的膠體穩定性之變化與材料生成機制。
而藉由結合式氣相分析技術取得粒徑分布、數量平均表面積、重量分布，我們可以成功分析出：(1)表面改質硫醇基化聚乙二醇配體之奈米銀粒子在酸性環境下之聚集與表面溶解動力學，(2)氧化石墨烯在進行混成反應前之基礎表面積、邊界長度等物理特性資訊，以及(3)氧化石墨烯與奈米銀粒子進行靜電組裝混成後，材料生成機制與環境因子對膠體穩定性之影響。
這個工作發展一套新型結合式且即時的氣相定量分析技術來量測混成式奈米材料之特性，透過ES-DMA結合即時性相輔分析方法：APM與ASAA，並搭配TEM等非即時影像分析技術，我們可提供完整混成式奈米材料之物理大小、重量、表面積、影像資訊，藉此評估其穩定性、基礎性質以及對應之功能性的影響。同時，此研究範疇亦可用於探討影響混成式奈米材料配方化學的重要參數之面向（e.g., 混成式奈米材料的組成與其在奈米科技應用上之表現性）。

We develop a new gas-phase quantitative approach for in-situ characterization of hybrid nanomaterial colloids using the concept of ion mobility instrumentation coupling. Electrospray-differential mobility analysis (ES-DMA), a gas-phase electrophoretic method, is used for quantifying particle size distributions and number concentrations of nanomaterial colloids. Aerosol particle mass analyzer (APM) and aerosol electrometer coupled to ES-DMA are used for in-situ measuring particle mass and surface area of size-classified aerosolized nanomaterial colloids, respectively. Transmission electron microscopy is employed complementary to provide the imagery of hybrid nanomaterial colloid.
Combining the information of the mobility size distribution, aerosol surface area measurement, and the aerosol mass-based distribution, we can quantify (1) the kinetics of aggregation and surface dissolution of silver nanoparticles (AgNPs) conjugated with thiolated polyethylene glycol (SH-PEG) under an acidic environment; (2) The lateral size, surface area of the synthesized graphene oxide (GO) colloid prior to hybridization; (3) The electrostatic-directed assembly of AgNP@GO colloids and the corresponding stability.
This study demonstrates a facile, prototype methodology to determine important formulation factors relevant to the formation of hybrid nanomaterial colloids and the performance in a variety of nanotechnological and bio-nanotechnological applications.

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