本研究在於製作一個有別於傳統的生物反應器，培養約10 ml菌液，小體積且低成本的自動化變型恆化器(Chemostat)。這個裝置是由市售的電子元件建構，如Arduinod板、發光二極體及微型幫浦等。整體的系統的運作皆由Arduino板自動化控制，利用發光二極體量測環境中細菌的光吸收值，即時觀察細菌的生長。並且，藉由微型幫浦持續輸入新的營養液與添加抗生素，同時依據細菌的生長狀況動態調整抗藥性濃度，使得細菌不斷演化為具有高抗生素抗藥性的突變細菌，這樣功能的裝置名稱為Morbidorstat。

We made a variant automated chemostat. The devices have small working volume of ~10 ml and low-cost different from the traditional bioreactor culture. The devices are built based on commercially available electronic components such as Ardunio board, light emitting diodes, and micropumps. The operation of the whole system is controlled with Arduino board automation. Using light emitting diodes measurement absorbance of bacteria in culture environment, observing the number of growth bacteria in real-time. Inject fresh medium and increase drug by micropump. Simultaneously, dynamically adjust the drug concentration according to growth of the bacteria. Allowing bacteria evolve mutant with high antibiotic resistance. The device we call the ’morbidostat’.

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