Antillaridine ((25R)-3β-amino-5-spirostene)與isojurubidine((25R)-3β- amino-spirostane)皆為具有螺甾骨架的胺類天然物，是由茄屬植物所單離出來。在2001年，由日本資生堂公司所發表的專利中，isojurubidine可作為抑制黑色素生成、沉澱之皮膚美白活化劑。
我們利用皂甘素(diosgenin)為起始物，經二次Mitsunobu反應作為關鍵步驟，成功合成antillaridine，總產率為20％。再經由一次氫化步驟合成出isojurubidine，產率為80%。再者，Antillaridine 為isojurubidine之前趨物，推測antillaridine亦可能具有美白活性之潛力。

The natural products antillaridine and isojurubidine were isolated from Solanum plants by Coll et al. In 2001, Shiseido company in Japan was granted a patent, in which isojurubidine was reported as a skin lightening agent with bleaching effect on pigmention. We successfully synthesized antillaridine in 20% over all yield by using diosgenin as a starting material and Mitsunobu reaction as the key step. Then antillaridine was hydrogenated with 10% Pd/C to give isojurubidine in 80% yield. Antillaridine is the precursor of isojurubidine; we expect antillaridine could also exhibit skin lightening effect.

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