我們利用共光程外差干涉的方式建構一個高靈敏度表面電漿共振生物感測器。透過調整四分之一相位延遲片的快軸方向來改變偏振態以得到較好的干涉品質，因此得到非常高的靈敏度，並利用鎖相放大器來提高我們的訊雜比。而加入四分之一相位延遲片之後可量測到約降低1000倍的量測濃度。我們利用羊的專一性抗原抗體來作為生物感測器研究。經由我們的實驗比較，我們的實驗架構在未調整靈敏度的情況下已經可以量測到55ng/ml的濃度訊號，比商用儀器Biacore X量到更低的濃度訊號。而調整四分之一相位延遲片的快軸之後，我們更可以清楚量測到11ng/ml的專一性蛋白質濃度。而我們利用已知折射率的蔗糖水溶液估計得到本系統的解析度約為 ，也比商用儀器來的高。

We have established a high resolution and real-time detection surface plasmon resonance biosensor based on common-path heterodyne interferometry. It could achieve very high sensitivity by adjusting the fast axis of a quarter waveplate (QWP), and have better signal-to-noise ratio by using a lock-in amplifier. The system with QWP can measure the concentration down to three orders than that without quarter waveplates. The measurenent targets are biospecific antibody and antigen of sheep. Our setup could measure low concntration as low as 55ng/ml of anti-sheep IgG without QWP, which is better than that of Biacore X system by Biacore Inc.. We could measure concentration as low as 11ng/ml after added two QWPs in our setup. The system is estimated to have the resolution as low as .

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