近年來，藉由外在環境如溫度、pH值的變化，進而刺激藥物釋放的藥物載體系統，相較起傳統的藥物載體，精確且有效許多。在體內惡性腫瘤與發炎部位的周圍環境，常同時伴隨著兩種生理因子的變化：一是患部體溫的上升，二是發炎組織 pH值的下降。因此，微米藥物載體經過適切的設計，使其具有雙重刺激的反應，可以增強藥物載體分辨正常與發炎組織的能力，達到更高的標的效率與治療效能。
目前研究顯示，具有多重刺激反應的藥物載體結構複雜、製程較繁複，藥物包覆率、載體均一性、相容性及對患部的反應性仍低。為改善上述問題，我們利用微流道技術設計thermo-sensitive porous shell / pH-sensitive core beads應用於藥物載體系統上，其殼層的結構由PLGA以及gelatin所組成，內部利用NPCS形成一水相的核層，大小約為300μm左右，並可以利用原位注射的方式注入到患部，在患部因為環境因子 (溫度、pH值)改變的刺激，使此載體進行雙開關調控的藥物釋放。第一個開關調控是透過溫度敏感性，當溫度升高超過38℃時，殼層上的gelatin會先融化 (unplug)，產生殼層上多孔的通透結構，接著由第二個開關調控，在酸性環境 (pH 6.8~6.0)中，體液通過gelatin融化後的孔洞進入核層，酸敏感性的NPCS水膠會變成溶液態而流出，進行藥物的釋放。
論文中主要分為三大主題。首先利用微流道系統製備均一性高、具有生物相容性、藥物包覆率及球徑大小可簡單控制的微米藥物載體，並觀察其表面型態與內層結構。接著，我們對製備出的藥物載體進行體外釋放 (in vitro)的實驗，以證實此載體具有溫度敏感及pH敏感性，能成為新型具雙重刺激反應功能的藥物載體。最後，我們以即時監測的方式測試載體的動態釋放變化，證實此為一能在患部進行雙開關調控的藥物釋放載體。

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