我們使用 Liu 和 Eisenberg 在 2014 年開發的泊松-費米理論研究了鉀離子
通道內的離子運輸機制 (KcsA)。我們提出了解釋 KcsA 的 K+ 運輸功能分
子的結合和解綁定循環。該理論的輸出包括各種循環狀態下每個 K 離子的
電和空間能。我們計算由軟體 PDB2PQR 提供的 KcsA 結構的七個結合位
點處的電勢和空間勢。循環狀態的原子和數值結果可用於描述 KcsA 通道
的 K 離子依序通過的傳輸機制。

We used the Poisson-Fermi theory developed by Liu and Eisenberg in 2014
to study the ion transport mechanism of potassium ion channels (KcsA).We
propose a binding and de-binding cycle to explain KcsA’s K+ exchange function
molecule. The output of the theory includes electric and steric energies
of each K ion in various cyclic states. We calculate the electric and steric
potentials at seven binding sites of the KcsA structure provided by the software
PDB2PQR .The atomic and numerical results of the cyclic states can
be used to describe the transport mechanism of a single file of K ions through
the KcsA channel.

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