Postsynaptic density (PSD)為後突觸膜下方，由超過三十多種蛋白質聚集而成的圓盤狀細緻結構，由其組成蛋白質與所在的位置推測，PSD與神經傳導 (neurotransmission)及突觸的可塑性 (synaptic plasticity)有極為密切的關連。在樹突小刺 (dendritic spine) 中，PSD位於突觸小刺的頭部頂點，正對前突觸活化區域處。過去許多對於PSD組成蛋白的研究發現，PSD的組成中含有大量的tubulin及其他與microtubule相關的蛋白質，且於PSD的結構中發現與microtubule有密切關係的PSDSU結構，然而卻極少在樹突小刺中，PSD的附近觀察到microtubule的存在。我們實驗室首先利用混濁度及離心沉澱實驗證明PSD與microtubule有能力聚合在一起形成MT•PSD complex，且MT•PSD complex的形成可能使得PSD的結構發生改變。並更進一步以穿透式電子顯微鏡觀察證明PSD的確可與microtubule接合。當microtubule形成時，PSD的結構被改變，異於典型PSD緊密堅實的結構，PSD形成較為鬆散的結構和microtubule相接。觀察其接合點發現，PSD可以形成特殊的構造接在microtubule邊緣或跨越其上，這些構造不只連結了PSD與microtubule，更影響microtubule的生長方向，且可能幫助穩定microtubule或調控microtubule生長。

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