本論文的研究在探討以反式-4-羥基-L-脯胺酸與樟腦磺醯胺合成
之新型掌性有機催化劑35，催化異丁醛與反式-β-硝基烯類進行不對
稱Michael 反應，僅需5 mol%催化量即可有效率地得到最高99%產
率及最高95%鏡像超越值之γ-硝基醛產物；催化劑35 亦可有效率地
催化α-單取代醛類加成至反式-β-硝基苯乙烯，僅需1 mol%催化劑
35 催化丙醛加成可得到95%產率、98%鏡像超越值及86/14 非鏡像立
體選擇性之結果，使用5 mol%催化劑35 催化異戊醛加成可得到92%
產率、99%鏡像超越值及99.6/0.4 之非鏡像立體選擇性。

This thesis dealt with the development of novel organocatalyst 35
which is derived from the coupling of trans-4-hydroxy-L-proline and
N-phenyl-camphorsulfonamide. Organocatalyst 35 is proven to be a
powerful catalyst (5 mol% loading) for the asymmetric Michael reaction
of isobutyraldehyde to nitroalkenes with high chemical yields (up to 99%)
and enantioselectivities (up to 95%). Treatment of α-substituted aldehyde
with trans-β-nitrostyrene in the presence of 1-5 mol% organocatalyst 35
and 1-5 mol% p-nitrobenzoic acid generated synthetically useful chiral
γ-nitroaldehyde with high chemical yields and excellent enantio-(98-99%)
and diastereoselectivities(86/14 – 99.6/0.4).

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