人體呼出氣體的檢測，是日趨重要的非侵入性健康狀態檢測的方式。慢性肺阻塞(COPD)與支氣管性氣喘(BA)，在許多方面十分相像，但治療方式大有不同，導致在臨床上很難快速診斷，並進行治療。本研究利用熱脫附儀氣相層析質譜儀(TD-GC-MS)聯用系統，針對COPD病患、BA病患、與未患病的常人呼出氣體樣品進行分析，證明透過TD-GC-MS系統可以成功分析樣品中化合物, 並且以此區別COPD病患、BA病患以及非病患的差異。
在本研究中，先利用每次檢驗都會出現、因吸附材料裂解而產生的六甲基環三矽氧烷 (Cyclotrisiloxane, hexamethyl-)作為內標，計算各檢驗到的化合物，相對於六甲基環三矽氧烷的相對濃度。接者，先簡單的比較化合物出現機率，確定可以用檢測到的化合物對研究對象分群。再用決策樹法細分，透過特定的化合物鑑定順序判定待測者的狀態，為常人、COPD 病患或是BA 病患。最後，以交叉比對的方式，證實此研究方式並非只適用於特定群體。
在本研究中，以耗時極短的分析方式，僅以總共50個呼氣樣品即可達到常人、COPD 病患與BA 病患分別為高達100%、94%與70%的平均分辨正確率。

Human exhaled breath measurement is one of important non-invasive health monitoring methods. The symptoms of bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) are similar, but different treatments for these two diseases. In this research, thermal desorption (TD) tendon with gas chromatography–mass spectrometry (GC-MS) system has been used to develop a screen method for the COPD patients, BA patients, and normal people.
In this research, “Cyclotrisiloxane, hexamethyl-“has been used as an internal standard for the evaluation of the relative concentration for all the detected volatile organic compounds (VOCs). First, we compare the relative concentration of VOCs from empty airbags and from the samples that were exhaled from COPD, BA patients, and normal people. Then, decision tree with deliberately ordered VOCs is used to identify the situation of every object. Cross validation is used to verify the data between the certain groups of samples. The breath from these three kinds of people could be simply distinguished and the average classification accuracy of normal people, COPD patients and BA patients are 100%, 94% and 70% respectively.

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