根據奈米金粒子的高電位、生醫影像的特性，適用於癌症治療藥物輸送上，並利用基因藥物的發展達到癌細胞毒殺之目的。因奈米金粒子不同形態所反映的光學的性質不同，並為獲得較好藥物傳遞、生物相容性和細胞吞噬效果，本研究將探討球狀(spherical)、桿狀奈米金粒子(NR)，及金納米粒子尺徑的不同。製備結果，經由UV光譜儀、SEM、TEM作金粒子的尺徑及大小測定，可得球狀奈米金分別尺徑為13、32、40 nm；以及桿狀奈米金分別徑長比為2、2.5、3。再由生物性電泳了解與金粒子作為VEGF siRNA結合橋樑的寡去氧核苷酸(ODN)結合情形；進一步發展為VEGF siRNA於HeLa cell的VEGF蛋白抑制情形，由蛋白質電泳與西方點墨法測試。最後再以細胞流式儀與共軛焦顯微鏡觀測細胞吞噬造成的細胞行為影響。並由結果發現VEGF siRNA確實可造成癌細胞趨向於凋亡之途徑。

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