細胞治療在組織工程與再生醫學的領域上，為一相當具有前瞻性的治療方法。我們先前與清華大學化工系宋信文教授的團隊合作，利用細胞不會貼附在甲基纖維素水膠的特性，開發出一能生產大小均一且可經針頭注射的3-D臍帶血間葉幹細胞/人類臍帶靜脈內皮細胞 (cbMSC/HUVEC) 均勻混合細胞球體生產系統。探討此均勻混合細胞球體的增生、分佈及最佳化等特性。體外實驗結果顯示，此cbMSC與HUVEC均勻混合於細胞球體內部並具有完整的細胞外間質及黏附性蛋白，可以形成穩定的類血管網狀結構，也找出促進此類血管網狀結構形成的相關機制。證實此均勻混合細胞球體確實有類血管形成的能力。在體內實驗，我們將此cbMSC/HUVEC均勻混合細胞球體利用針頭植入缺血肌肉組織進行血管新生的治療。實驗結果顯示此均勻混合細胞球體的確可以促進缺血性肌肉組織血管新生。

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