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研究生： 張書維
Jang, Shu-Uei
論文名稱： 氣動式微閥門晶片輔助微量多氯聯苯與重金屬之快速分析研究
Multilayer microfluidic chip with pneumatic microvalves assisting for rapid analysis of trace polychlorinated biphenyls and heavy metals
指導教授： 凌永健
Ling, Yong-Chien
口試委員: 黃賢達
王先知
學位類別： 碩士
Master
系所名稱： 工學院 - 奈米工程與微系統研究所
Institute of NanoEngineering and MicroSystems
論文出版年： 2011
畢業學年度： 99
語文別： 英文
論文頁數： 62
中文關鍵詞： 微晶片
相關次數： 點閱：3  下載：0 
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    • 環境中重金屬與多氯聯苯會對人體健康及自然生態造成極大的影響，傳統重金屬與多氯聯苯分析方法多費時、費力、費劑。微流體實驗室晶片(Lab on a Chip) 微小化研究和操作尺度，在化學分析的應用極廣，從樣品前處理、樣品分離、試劑反應、至偵測等複雜功能，整合前述步驟於一小面積微流體晶片上，減少試劑用量，加快分析速度，達到綠色分析化學目標。本實驗利用工程設計整合氣動式微閥門晶片測試新穎材料如石墨烯(graphene)和磁性奈米粒子(MNPs-PAA)，進行多氯聯苯與重金屬(Mn2+, Co2+, Cu2+, Pb2+ )之吸/脫附研究。使用非光阻式之壓克力板為母模，利用自動化控制氣動式微流閥系統，以操控吸/脫附反應。實驗結果顯示，MNPs-PAA可應用在微流體晶上，並證明graphene材料從成功製造出以來首次對PCBs之吸附，較傳統方法快速、低廉、環保，有助於綠色的綠色奈米分析化學的推廣。

    1.1 INTRODUCTION - 8 - 1.2 RESEARCH OBJECTIVE - 10 - 1.2.1 Lab-on-chip system - 10 - 1.2.2 Motivation and objectives - 11 - 1.3 LITERATURE SURVEY - 12 - 1.3.1 Pneumatic PDMS microvalves - 12 - 1.3.1.1 The displacement of PDMS membrane - 14 - 1.4 EXPERIMENTAL SECTION - 15 - 1.4.1 Materials and reagents - 15 - 1.4.1.1 Synthesis of materials - 16 - 1.4.1.2 PDMS characteristics - 17 - 1.4.2 Experimental apparatus - 18 - 1.4.3 Experimental procedure - 19 - 1.4.3.1 Design - 19 - 1.4.3.2 Fabrication - 22 - 1.4.3.3 Chromatography and mass analysis - 24 - 1.4.3.4 Detection process and control system - 24 - 1.5 RESULTS AND DISCUSSION - 27 - 1.5.1 Characterization of PMMC - 27 - 1.5.1.1 Performance of pneumatic microvalve - 27 - 1.5.1.2 The flow rate of PMMC - 30 - 1.5.2 Determination of PCBs - 31 - 1.5.2.1 Adsorbents’ performance comparison - 34 - 1.5.3 Material characterization - 36 - 1.5.4 Adsorption simulation of PCBs on RGO - 38 - 1.6 CONCLUSIONS - 41 - 1.7 REFERENCES - 42 - 2.1 INTRODUCTION - 44 - 2.2 EXPERIMENTAL SECTION - 47 - 2.2.1 Materials and reagents - 47 - 2.2.1.1 Preparation and immobilization of MNPs-PAA - 47 - 2.2.2 Experimental apparatus - 48 - 2.2.3 Experimental procedure - 49 - 2.2.3.1 Design - 49 - 2.2.3.2 Fabrication - 51 - 2.2.3.3 Detection process and control system - 51 - 2.3 RESULTS AND DISCUSSION - 54 - 2.3.1 The flow rate of PMMC - 54 - 2.3.2 Determination of heavy metal ions - 55 - 2.3.2.1 On-line pre-treatment - 56 - 2.3.3 Material characterization - 58 - 2.4 CONCLUSIONS - 60 - 2.5 REFERENCES - 61 -

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